The benefits of its use include efficacy, low cost, ease of detection, removal, and disposal. Mabselect sure antibody purification resin ge healthcare life. Evaluation of new affinity chromatography resins for. Eternal chemical company emergency contact phone numbersfax numbers. The weak cation exchange multimodal ligand enables high binding selectivity. Mabselect sure resin features an engineered, alkalitolerant rprotein a ligand for mab purification. Dear customer, enclosed please find the safety data sheet sds for the. Use of sodium hydroxide for cleaning and sanitizing. Load on columns product load mab1 gl resin load mab2 gl resin mabselect prisma 58 63 mabselect sure lx 46 43 mabselect sure 39 36 0 500 grams puri ed per cycle. Thats why we opened one of the worlds largest agarose manufacturing facilities, capable of meeting 30% of global demand.
Mabselect sure and mabselect sure lx resins are designed with the same base matrix as mabselect resin, but have an alkalistabilized protein a ligand that allows the use of 0. Wildcard can be used to search when only a part of a number or word is known. Mabselect sure mabselect sure is an alkalitolerant protein aderived bioprocess resin for capturing monoclonal antibodies from large volumes of feed by packed bed chromatography. For optimal user experience, please view this site in chrome, firefox. The medium is based on a highly crosslinked agarose matrix with a recombinant protein a ligand. Compared with mabselect sure lx, the optimized base matrix of mabselect prisma offers an up to 40% increase in dbc at a. A nextgeneration protein a resin for improved productivity. Capto adhere capto adhere is a multimodal bioprocess medium for intermediate puri. Mabselect sure ge healthcare, 17543801, pack of 25 ml. Here, a safety factor of 20% was used in loading of a 2000 l bioreactor harvest with a mab titer of 4 gl.
Tear open the foil bags and remove the rapidex resin pouch. Names, addresses, and phone numbers of the manufacturer or supplier. In this application note, the effects of treating mabselect sure protein a affinity resin with 20 mm paa every fourth process cycle for more than 100 cycles were. It aids in the production of our praesto ap and apc resins, biosimilars to mabselect sure lx and mabselect sure respectively, with feedback from customers expressing comparable capabilities across multiple antibodies. Keep product and empty container away from heat, open flames, and other sources of ignition. Tips based automated protein and plasmid purification for. Toxicological information no information found on specific symptoms. Packinplace pack at flow ratespressures up to the limits. This flow should yield a pressure higher than the desired operating pressure for all column steps. The information in this msds relates only to the specific materials designated, and to the specific aquaresin products identified in our instructions. View or download selected quality management system documents for repligen products, including iso certifications, environmental policy statement, user guides, regulatory support files, certificates of analysis examples, material safety data sheets, quality and animalfree statements. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy.
As a service to its customers, dow can provide names of information. Bioprocess chromatography resins are developed and supported for productionscale chromatography. Hitrap mabselect sure hitrap mabselect hitrap mabselect xtra. Capto mmc impres capto mmc impres fig 1 is a bioprocess chromatography medium resin for highresolution polishing of monoclonal antibodies mabs and other biomolecules. Handle in accordance with good industrial hygiene and safety practice. There are however some products that are not yet included. The resin can withstand rigorous cip and sanitization procedures with 0. Mabselect sure lx protein a resin cytiva, formerly ge healthcare. It does not relate to use in combination with any other materials or processes. Refer to other sections of this msds for information regarding physical and health hazards, respiratory protection, ventilation, and personal protective equipment. Safety data sheets cytiva, formerly ge healthcare life sciences. Some features of this site may not function properly. Place in a closed container approved for transportation by appropriate authorities.
Figure 2 shows dbc of mabselect prisma as compared with mabselect sure and mabselect sure lx resins at different residence times. Take precautionary measures against static discharges. Hitrap mabselect sure pcc ge healthcare, 17549112, pack of 1. Mabselect sure is a protein a affinity medium for capturing mabs at process scale. Our msds database is an easy to use, do it yourself tool, and best of all. The contents and format of this msds are in accordance with eec commission directive 200158ec. Phynexus customer service and technical support has been outstanding, and the staff has been responsive and very knowledgeable when helping us establish purification protocols. Moreover, phynexus was very supportive in addressing specific needs for our enzymes, providing highly reliable products of outstanding quality. Mabselect sure pcc affinity resin offers exceptional capacity at short residence time, making it wellsuited for. Mabselect sure lx is a protein a affinity resin with very high dynamic binding capacity at extended residence times. It addresses todays clinical trial material demands for high productivity together with costeffective mab capture, and is purposedesigned and evaluated for phase i and ii clinical trials, where typically less than 20 reuse cycles are performed. Improved capture with better productivity in mab bioprocessing. Mabselect sure antibody purification resin cytiva, formerly. The inhalation of high vapor concentration may cause a headache and nausea.
Packing mabselect and mabselect sure resins using verified. The mabselect sure ligand was developed by protein engineering of one of the. The toxicological properties of this preparation have not been fully investigated. While phosphate buffers are the most widely used with cht, buffer systems composed of, for example, mes, hepes, tris, imidazole, or. Praesto apc is an agarosebased protein a resin designed on a novel, highflow base matrix. Mabselect sure lx ge healthcare, 17547402, pack of 200. Preparation should include fitting the thread shield to the entry thread. The information contained in this material safety data sheet has been compiled from sources which global dental impression trays, inc. Mabs tr558a document id mabs tr558a issued date 1997.
Discussion and conclusions a nextgeneration protein a resin, mabselect prisma, with significantly increased alkali stability. Material safety data sheet according to regulation ec no 19072006 reach. Ge healthcare life sciences data file 28987062 aa affinity chromatography mabselect sure lx 1 medium characteristics 1 wellestablished in bioprocessing 1 high binding capacity meets modern processing demands 2 high alkaline stability extends working lifetime 2 rigid, highly crosslinked matrix allows high flow rates2. Phynexus automation automated protein and plasmid purification. No significant differences in dynamic binding capacity were observed among human antibodies on mabselect sure. Jul 12, 2015 your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Details of the supplier of the safety data sheet company. Identification product identifier stepantex td560 other means of identification product code 2072 recommended use surfactant recommended restrictions for industrial use only. The weak cation exchange multimodal ligand enables high binding selectivity in a broad phsalt window compared with traditional ion. If you cannot find the msds you require in this database, please contact your local technical support group. Like many of ges protein a chromatography resins, mabselect sure uses oriented ligand coupling for excellent binding capacity. Mabselect sure has an alkalitolerant rprotein a ligand that allows the use of rigorous and costeffective cip and sanitization protocols based on 0. Do not use knives to open foil bags if the blue section appears cloudy as pictured, carefully mix until an even blue is achieved making sure not to remove clips.
Impact of sporicidal agent on mabselect sure protein a resin. This information is provided in good faith, and as of the date of this document, is believed to be correct. Alkali tolerance, high capacity and low ligand leakage in combination with the rigid base matric makes mabselect sure lx highly suitable for purification of monoclonal anitbodies for clinical. Phynexus provides automated protein and plasmid purification columns with up to 95% yields for high throughput liquid handling robots. This resin for monoclonal antibody mab purification contains a rigid, highflow agarose matrix that delivers excellent pressureflow properties. Compared with mabselect sure lx, the optimized base matrix of mabselect prisma offers an up to 40% increase in dbc at a residence time of 2. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Basf corporation 100 park avenue florham park, nj 07932, usa.
Material safety data sheet axson north america, inc. Further, the ligand is protease stable leading to lower ligand leakage. Purification performance, in terms of yield and purity, was comparable for the different protein a resins. Safety data sheet freeman 601 epoxy laminating resin. This product is purchased from the manufacturer by appleton and is distributed with no modification other than packaging, as applicable. Hitrap mabselect sure pcc ge healthcare, 17549112, pack.
Like many of cytivas protein a chromatography resins, mabselect sure uses oriented ligand coupling for excellent binding capacity. The elution ph for each human antibody was similar on mabselect sure and igselect ph 3. Chemical product and company identification product name. This product is a liquid acrylic based resin with an acrylat characteristic odor. Antibodies, antibody purification and characterization, mabselect mab purification, protein a, g and l resins, supplementary products more. Mabselect sure is an alkalitolerant protein aderived bioprocess resin for capturing monoclonal antibodies. The msds database contains a majority of the product range. Safety data sheets cytiva, formerly ge healthcare life.
In case of exposure to a high concentration of vapor or mist, remove person to fresh air. Minicolumns prefilled with mabselect sure lx protein a resinthe chromatography resin offers high alkaline stability and high binding capacity for high. The terms of this safety data sheet sds do not create or infer any warranty, express or implied, including by incorporation into or reference in the sellers sales agreement. The ligand provides greater stability than conventional protein a affinity resins in the alkaline conditions used in cleaninginplace cip and sanitization protocols. Mabselect sure antibody purification resin ge healthcare. Safety data sheet freeman 601 epoxy laminating resin date of preparation. This product is a liquid acrylic based resin with a characteristic light odor. Mabselect is developed for costeffective high throughput processing of large amounts of feed. This product may cause skin, eyes and respiratory system irritation, and skin sensitizationallergic reaction by skin contact.
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